Paper 02 · White paper · Hemodynamic model
Abstract
This paper argues that age-related vascular stiffening may impair the pulsatile mechanical forces that support periarterial cerebrospinal fluid exchange, glymphatic clearance, and downstream meningeal lymphatic drainage. Within this framework, amyloid accumulation is treated not solely as an initiating lesion, but as a downstream manifestation and amplifier of broader clearance failure in the aging brain.
Key findings
The model integrates vascular compliance, sleep-dependent CSF dynamics, and extracranial lymphatic outflow into a single neurodegenerative framework.
Arterial stiffness may degrade the coupling between vascular motion and perivascular fluid movement before overt cerebrovascular disease is clinically obvious.
The paper advances falsifiable predictions that can be tested through pulse-wave, sleep, lymphatic, and neuroimaging measurements.
Downloads
Access the corrected final PDF for citation, review, and distribution.
Systems-clearing figure
Mechanistic systems figure summarizing periarterial inflow, sleep-linked clearance behavior, and cervical lymphatic outflow.
Platform architecture figure
Architecture illustration showing how LymphLens, LymphRelief, and LymphRestore can be framed within a broader intervention and measurement ecosystem rather than a single standalone device.
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